Table 4.
Comparison of MRI parameters between the non-PD and PD groups.
| Non-PD group (n = 6) | PD group (n = 4) | P value | |
|---|---|---|---|
| ADC (× 10−3 mm2/s)a | 0.66 (0.61–0.68) | 0.69 (0.67–0.72) | 0.051 |
| Ktrans (× 10−3/min)a | 152.20 (107.47–228.01) | 96.94 (43.51–346.04) | 0.286 |
| kep (× 10−3/min)a | 836.33 (628.82–1082.32) | 741.29 (301.41–956.28) | 0.670 |
| ve (× 10−3)a | 195.00 (135.30–368.89) | 148.30 (128.38–410.13) | 0.522 |
| vp (× 10−3)a | 4.93 (0.38–8.46) | 5.53 (2.38–24.52) | 0.522 |
| Volume (cm3)a | 5.06 (0.80–14.93) | 14.16 (4.88–65.93) | 0.136 |
| ΔADC% | 46.71 (7.71–112.81) | − 1.35 (− 6.16 to 6.79) | 0.011 |
| ΔKtrans% | − 11.31 (− 75.51 to 75.54) | − 30.74 (− 72.97 to 31.48) | 0.670 |
| Δkep% | − 50.11 (− 97.54 to − 7.29) | − 63.20 (− 64.85 to − 41.27) | 1.000 |
| Δve% | 122.14 (5.17–440.48) | 57.46 (− 39.27 to 410.41) | 0.670 |
| Δvp% | − 11.51 (− 97.55 to 520.64) | − 38.44 (− 83.39 to 64.20) | 0.522 |
| ΔVolume% | -3.26 (− 23.63 to 53.20) | 2.61 (− 7.58 to 7.36) | 1.000 |
Numbers are medians and ranges in parentheses.
MRI, magnetic resonance imaging; ADC, apparent diffusion coefficient, Ktrans, volume transfer constant; kep, rate constant; PD, progressive disease; ve, volume fraction of the extravascular extracellular matrix; vp, blood plasma volume.
aData from baseline MRI.