Fig. 1. m6A methyltransferase KIAA1429 was upregulated in lung cancer specimens.
A Heatmap showed the expression of several candidate m6A regulators in gefitinib-resistant NSCLC cell (PC9-GR) and parental sensitive cells (PC9). B RT-qPCR showed the KIAA1429 mRNA expression in the gefitinib-resistant NSCLC cell (PC9-GR) and other NSCLC cell lines (H1299, A549, and PC9). C RT-qPCR detected the KIAA1429 expression in NSCLC patients’ samples as compared to normal tissue samples. D Survival analysis based on TCGA database (http://gepia.cancer-pku.cn/) for lung cancer patients with high or low KIAA1429 expression. E Survival analysis based on clinical cohort for NSCLC patients with high or low KIAA1429 expression. Bar graphs indicate the means ± SD. *P < 0.05, **P < 0.01.