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. 2021 May 17;11:10416. doi: 10.1038/s41598-021-89978-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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SM images of flat mounts of the bottom side of the transwell show filopodia that extend from the upper side through the pores of the insert in the Efemp1^WT/WT:C5^+/+ cultures (WT), vs. deposition of extracellular material in Efemp1^R345W/R345W:C5^+/+ (KI), Efemp1^R345W/R345W:C5^-/- (KIC5KO) and Efemp1^WT/WT:C5^-/- (C5KO) cultures. The graph represents the percentage of deposits measured in SM images using a pinpoint technique (see methods section). Data represented as average ± SEM, the numbers inside the bars indicate the amount of cultures used for quantification for each genotype. Scale bar = 10 μm. N = 2 Efemp1^WT/WT:C5^+/+ (WT), n = 5 Efemp1^R345W/R345W:C5^+/+ (KI), n = 12 Efemp1^R345W/R345W:C5^-/- (KIC5KO), n = 2 Efemp1^WT/WT:C5^-/- (C5KO).