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. 2021 May 4;9:682675. doi: 10.3389/fchem.2021.682675

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Copyright © 2021 Wang, Ni, Liu and Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Peptide-based PPI inhibitors targeting p53-MDM2. (A) The structure of γ-AApeptide γ-AA3. (B) The structure of Sulfono-γ-AApeptide PS1, PS10 and PS11. (C) The structre of D-Sulfono-γ-AApeptide γ-AA4. (D) The scheme of chemical modifications for α/Sulfono- γ-AApeptides.