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Peptide-based PPI inhibitors targeting APC-Asef PPI. (A) Structural overview of MAI150/APC PPI complex (PDB ID: 5IZ6). APC is shown as a solvent-accessible surface (pink), and MAI-150 is depicted by sticks (carbon atoms: cyan). (B) Development scheme of MAI analogs as APC-Asef PPI inhibitors. (C) Binding interactions between MAI-400 (carbon atoms: yellow) and APC (carbon atoms: pink). The red dashed lines represent the intramolecular hydrogen bonds between MAI-400 and APC.
