Table 3. Adjusted mean differences (AMD), including 95% CI, p-values, and Cohen’s d, between the intervention and control group at T2 and T3.

Outcome	Time point	AMD [95% CI]	p	Cohen’s d
ACT	T2	6.00 [5.31; 6.69]	< 0.001	1.69
	T3	4.71 [3.99; 5.43]	< 0.001	1.27
AQLQ total	T2	1.32 [1.18; 1.45]	< 0.001	1.78
	T3	0.91 [0.76; 1.06]	< 0.001	1.14
SGRQ total	T2	–18.5 [–16.3; –20.8]	< 0.001	–1.57
	T3	–15.5 [–12.9; 18.1]	< 0.001	–1.16
Exertional dyspnea	T2	–2.38 [–2.77; –1.98]	< 0.001	–1.17
	T3	–2.28 [–2.71; –1.85]	< 0.001	–1.03
PHQ-9	T2	–3.98 [–4.73; –3.24]	< 0.001	–1.04
	T3	–1.96 [–2.70; –1.23]	< 0.001	–0.53
GAD-7	T2	–3.52[–4.23; –2.80]	< 0.001	–0.95
	T3	–2.01 [–2.74; –1.29]	< 0.001	–0.54
heiQ-SK	T2	0.58 [0.50; 0.67]	< 0.001	1.28
	T3	0.45 [0.35; 0.54]	< 0.001	0.89
IPQ-7	T2	2.02 [1.66; 2.37]	< 0.001	1.10
	T3	1.79 [1.37; 2.22]	< 0.001	0.81
IPQ-4	T2	0.94 [0.61; 1.28]	< 0.001	0.53
	T3	0.23 [–0.12; 047]	0.200	0.13
IPQ-3	T2	1.40 [0.99; 1.81]	< 0.001	0.66
	T3	0.59 [0.16; 1.01]	0.011	0.27
MARS-D*1	T2	0.55 [0.28; 0.82]	< 0.001	0.41
	T3	0.37 [0.08; 0.66]	0.003	0.24
WAS	T2	1.18 [0.82; 1.53]	< 0.001	0.65
	T3	1.01 [0.66; 1.36]	< 0.001	0.56
		Odds ratio [95% CI]
SPE*2	T2	0.32 [0.20; 0.52]	< 0.001
	T3	0.73 [0.45;1.14]	0.163

ACT, Asthma Control Test (primary endpoint); AQLQ, Asthma Quality of Life Questionnaire;

CI, confidence interval; GAD-7, Generalized Anxiety Disorder Questionnaire; heiQ-SK, Health Education Impact Questionnaire: scale of Skills and techniques; IPQ, Illness Perception

Questionnaire; IPQ-3, How much control do you feel you have over your asthma?; IPQ-4, How much do you think your treatment can help with your asthma?; IPQ-7, How well do you feel you understand your asthma?; MARS-D, Medical Adherence Rating Scale; PHQ-9, Patient Health Questionnaire 9; SGRQ, St. George’s Respiratory Questionnaire; SPE, Subjective Prognosis of Employment Scale; WAS, Work Ability

Score *¹ based on robust regressions; *² based on ordinal logistic regressions