eTable 6. Observational study. For each outcome, model 1 is compared to model 2; the mean differences (M + 95% CI) from model 2 are between the time of measurement at 12 months and the point of randomization/ start of rehabilitation.
| Outcome | Model comparision* | Pre-post differences between T0 (randomization) and 12 months after rehabilitation | Pre-post differences between start of rehabilitation and 12 months after rehabilitation |
| Chi² (df), p-value | M [95% CI] | M [95% CI] | |
| ACT scores | 4.09 (6), p = 0.665 | 6.01 [5.51; 6.52] | 3.54 [3.03; 4.03] |
| AQLQ total | 12.44 (6), p = 0.053 | 1.19 [1.09; 1.30] | 0.80 [0.70; 0.90] |
| SGRQ total | 7.25 (6), p = 0.297 | –17.4 [–19.11; –15.62] | –12.77 [11.08; 14.45] |
| Resting dyspnea | 4.49 (6), p = 0.611 | –1.26 [–1.51; –1.01] | –0.799 [–1.04; –0.56] |
| Exertional dyspnea | 5.17 (6), p = 0.522 | –2.11 [–2.39; 1.83] | –1.67 [–1.94; –1.40] |
| Cough | 5.40 (6), p = 0.493 | –1.52 [–1.83; –1.21] | –1.06 [–1.34; 0.77] |
| Sputum | 8.68 (6), p = 0.193 | –1.04 [–1.30; –0.77] | –0.47 [–0.71; 0.22] |
| Pain | 2.62 (6), p = 0.855 | –1.35 [–1.63; 1.06] | –0.86 [–1.14; 0.58] |
| PHQ-9 | 3.06 (6), p = 0.801 | –2.61 [–3.09; 2.13] | –1.87 [–2.31; 1.43] |
| GAD-7 | 8.89 (6), p = 0.180 | –2.62 [–3.09; 2.14] | –1.90 [–2.31; –1.50] |
ACT, Asthma Control Test; AQLQ, Asthma Quality of Life Questionnaire; CI; confidence interval; df, degrees of freedom; GAD-7, Generalized Anxiety Disorder Questionnaire; M, mean;
PHQ-9, Patient Health Questionnaire 9; SGRQ, St. George’s Respiratory Questionnaire
*Chi²-difference test according to Satorra and Bentler (2001) for comparing model 1 (only for randomization of the same mean values between the intervention group and the control group) and model 2 (for all equivalent time points for the same mean values for the intervention and control groups)