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. 2021 May 17;11:10439. doi: 10.1038/s41598-021-89836-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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MafB^+/GFP mice showed impaired thymic recovery after sublethal total body irradiation (SL-TBI). (a–e) Thymi from 9-week-old wild-type (WT) (white bars, n = 6) and MafB^+/GFP (black bars, n = 6) mice were analyzed 28 days after SL-TBI. (a,b) Gross morphology of thymus. Scale bar: 1 mm. (c) Absolute thymus mass (mg; milligrams). (d) Normalized mass calculated as thymic mass divided by body mass (mg/g). (e) Total thymocyte number, measured using a haemocytometer. All data are shown as the means ± standard deviation (SD). *P < 0.05 (Student’s t test). (f) The thymi of MafB^+/GFP mice showed reduced MafB mRNA expression compared to those of WT counterparts. Total RNA was extracted from whole thymi of untreated 5-week-old WT (white bar, n = 6) and MafB^+/GFP (black bar, n = 6) mice. MafB mRNA expression was subsequently measured by qRT-PCR, and normalized to GAPDH mRNA expression. Data presented as the means ± SD. *P < 0.05 (Student’s t test). All data shown are representative results of at least 3 independent experiments using adult specimens from different litters (n ≥ 3).