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. 2021 May 17;11:10439. doi: 10.1038/s41598-021-89836-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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MafB^+/GFP mice showed impaired restoration of thymic architecture after SL-TBI. (a–d) Hematoxylin and Eosin (H.E.) staining of 9-week-old MafB^+/GFP and WT thymi paraffin serial sections (transverse), 28 days after SL-TBI. The borders of medullary region are indicated by black dotted lines. Scale bar: 200 µm. Multiple medullary region were observed in (a) untreated WT thymi, (b) untreated MafB^+/GFP thymi, and (c) SL-TBI-treated WT thymi. (d) SL-TBI-treated MafB^+/GFP thymi showed reduced number of medullary region compared to those of SL-TBI-treated WT littermates. Transverse sections of SL-TBI-treated MafB^+/GFP thymi frequently exhibited a single large medulla region (indicated by black arrows), which was rarely observed in SL-TBI-treated WT counterparts. (e) Quantification of medullary region per thymic lobe was performed based on H.E.-stained serial sections (approximately 800 sections) from SL-TBI-treated WT and MafB^+/GFP thymi. Data in (e) are shown as the means ± SD. *P < 0.05 (Student’s t test). All data shown are representative results of 3 independent experiments using adult specimens from different litters (n = 3).