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. 2021 May 17;11:10439. doi: 10.1038/s41598-021-89836-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Thymi from MafB^+/GFP mice displayed aberrant organization of medullary thymic epithelial cell (mTEC) clusters after SL-TBI. (a–d) ER-TR7 expression (green color, representing fibroblasts and other mesenchymal cells of the thymic capsule) and Keratin 14 expression (red color, representing mTECs) shown by immunofluorescence staining of 9-week-old MafB^+/GFP and WT thymi frozen sections (transverse), 28 days after SL-TBI. The borders of Keratin 14 positive mTEC clusters are indicated by white dotted lines. Scale bar: 200 µm. Similar organization of Keratin 14 positive mTEC clusters was observed in (a) untreated WT thymi, (b) untreated MafB^+/GFP thymi, and (c) SL-TBI-treated WT thymi. (d) Aberrant organization of mTEC clusters was prominently observed in SL-TBI-treated MafB^+/GFP thymi, which often exhibited a single large mTEC cluster (indicated by white arrows). All data shown are representative results of 3 independent experiments using adult specimens from different litters (n = 3).