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. 2021 May 17;11:10439. doi: 10.1038/s41598-021-89836-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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MafB^+/GFP mice showed signs of accelerated age-related thymic involution. (a–f) Hematoxylin and Eosin (H.E.) staining of 3, 5 and 10-month-old MafB^+/GFP and WT thymi paraffin sections (transverse). Scale bar: 200 µm. (a,b) 3 and 5-month-old WT thymi showed normal thymic architecture, judged by the presence of medullary region with a clear distinction between cortex (purple-colored regions) and medulla (pink-colored regions). Black asterisks indicate medullary region. (c) 10-month-old WT thymi displayed signs of age-related thymic involution, with slightly reduced number of medullary region and slight loss of distinction between cortex and medulla (relatively small intermixed pink and purple regions). (a,d) The thymi of 3-month-old MafB^+/GFP mice were histologically similar to those of WT littermates. (b,c,e,f) The thymi of 5-month-old and 10-month-old MafB^+/GFP mice exhibited slightly decreased number of medullary region compared to those of WT littermates. In contrast to WT counterparts, mutant thymi also displayed a greater loss of distinction between cortex and medulla, wherein a larger portion of the tissue area is occupied by medulla regions (pink) interspersed with cortex regions (purple). These observations suggest that MafB^+/GFP thymi showed signs of accelerated age-related thymic involution compared to WT thymi. All data shown are representative results of 3 independent experiments using adult specimens from different litters (n = 3).