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. 2021 May 17;11:10439. doi: 10.1038/s41598-021-89836-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Implications of radiation induced MafB gene for thymic regeneration and aging. Summary of radiation (SL-TBI) induced MafB gene and its possible functions for thymic regeneration and age-related thymic involution. MafB is drastically induced at 1 day after irradiation. Its induction was decreased in MafB^+/GFP mutant. In the case of WT, thymus is recovered after 28 days irradiation. On the other hand, MafB^+/GFP mutant showed partial recovery including medullary region and epithelial abnormalities. Aged MafB^+/GFP mice thymi showed signs of accelerated thymic involution with altered islets structures. Possible effects of MafB mutation on thymic cellular interaction; Mesenchyme derived regulation for TECs population could lead to change of the immature TECs marker expression such as FoxN1 and Krt5 which is evident after thymic irradiation. Such cellular changes in TECs population may affect to the thymic involution and thymocyte development.