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. 2021 May 17;11:10418. doi: 10.1038/s41598-021-89853-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Peptide production by islets after glucose stimulation. Peptide levels measured by LC–MS/MS for (a) mouse insulin-1, (b) mouse insulin-2 and (c) islet amyloid polypeptide (IAPP). Fold changes calculated as the ratio of Peak Area measured in 16.7 mM glucose and in 3.3 mM glucose for (d) mouse insulin-1, (e) mouse insulin-2, (f) islet amyloid polypeptide (IAPP). Peptide levels measured by LC–MS/MS for (g) glucagon and (h) somatostatin (SST-14). Fold changes calculated as the ratio of Peak Area concentration measured in 16.7 mM glucose and in 3.3 mM glucose for (i) glucagon and (j) somatostatin (SST-14). Peak Areas for glucagon were normalised to Peak Areas for glucagon internal standard. One-way Kruskal–Wallis analysis of variance was performed for the fold changes followed by Dunn’s correction for multiple comparisons (n = 9 samples from 3 isolations, each sample = 10 islets; p-values are shown for each comparison, significant differences are highlighted in red). All figures were produced in GraphPad Prism (version 8.4.1, https://www.graphpad.com).