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. 2021 May 17;11:10418. doi: 10.1038/s41598-021-89853-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Engraftment of cryopreserved islets in STZ-induced diabetes mouse model. (a) Fasting blood glucose measurements in diabetic mice transplanted with 800 fresh, DMSO-cryopreserved or DT6h-cryopreserved islets or vehicle (Matrigel), measured using portable glucose meter (n = 3–4 mice). (b) Fasting blood serum glucose measured using an immunoassay on day 75 days after transplantation (day 91 after first STZ injection). (c–f) Fasting blood glucose in individual diabetic mice transplanted with (c) 800 fresh islets, (d) Matrigel/vehicle only, (e) 800 DMSO-cryopreserved islets and (f) 800 DT6h-cryopreserved islets over the time course of the experiments. All plots were produced using GraphPad Prism (version 8.4.1, https://www.graphpad.com). STZ streptozotocin, Tx transplantation.