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. 2021 May 17;11:10426. doi: 10.1038/s41598-021-89707-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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12-HEPE exerted anti-atherosclerosis activity. (a) Mice were fed with either control diet with soybean oil or HFD with soybean oil for 2 months. During that time, mice were intraperitoneally injected with either 12-HEPE (100 ng/mouse) or vehicle 3 times/week, and then pulsatility index and resistive index were examined. Data are combined from 2 independent experiments. Each point represents data from individual mice. Statistical significance of differences was evaluated by means of 1-way ANOVA; *p < 0.05; **p < 0.01; N.S. not significant. (b) Mice were fed with HFD with soybean oil for 2 months. Mice were intraperitoneally injected with either 12-HEPE (100 ng/mouse) or vehicle at the last 4 consecutive days, and then pulsatility index and resistive index were examined 1 day after the final injection with 12-HEPE. Data are combined from 2 independent experiments. Each point represents data from individual mice; n = 7–8/group. Statistical significance of differences was evaluated by means of Mann–Whitney test; **p < 0.01.