Figure 3.

Restoring miR-378 further enhances the ISO-mediated improvement of hemodynamics and myocardial damage in MI/RI mice. (A, B) The values of LVSP and LVEDP in MI/RI mice after ISO treatment and up-regulating miR-378; (C) The values of ± dp/dt_max in MI/RI mice after ISO treatment and up-regulating miR-378; (D-G) The levels of AST, CK, CK-MB and LDH in MI/RI mice after ISO treatment and up-regulating miR-378; (H-L) The levels of oxidative stress-related indices SOD, MDA, GSH-Px, CAT and NO in MI/RI mice after ISO treatment and up-regulating miR-378; (M) HE staining results in MI/RI mice after ISO treatment and up-regulating miR-378 (× 200; Scale bar = 50 μm); * vs the I/R group, P < 0.05; # vs the I/R + ISO group, P < 0.05; 6 mice in each group (A-C) and 5 mice in each group (D-M). The data were expressed in the form of mean ± standard deviation. One-way ANOVA was used for data analysis, and Tukey’s post hoc test was used for pairwise comparison after ANOVA analysis.