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. 2021 Apr 15;13(4):2283–2295.

Figure 2.

Figure 2

miR-320-3p reduced KLF5 and HIF1α expression and targeted the two genes directly. A. The mRNA expression of KLF5 and HIF1α in normal, control inhibitor/miR-320-3p inhibitor groups or control mimics/miR-320-3p mimics groups. B. PASMCs were transfected with control mimics or miR-320-3p mimics in normoxia or with control inhibitor or miR-320-3p inhibitor in hypoxia and KLF5 and HIF1α protein expression were analyzed. C, D. PASMCs were co-transfected with control mimics/miR-320-3p mimics and KLF5-WT/KLF5-Mut plasmid or HIF1α-WT/HIF1α-Mut plasmid for 48 h, and then the luciferase activity was detected. *P < 0.05, **P < 0.01. (WT, wild type; Mut, mutative type).