Table 4.

Expression levels of sCr, NF-κB, caspase-3, TLR3, IL-1β, and TNF-α

	Control (n=84)	DMED group (n=84)	t	P
sCr (mol/L)
T0	79.12±9.75	78.18±8.84	0.655	0.514
T1	77.15±10.02	79.28±11.46	1.282	0.202
T2	84.26±15.54	83.48±17.26	0.308	0.759
T3	93.46±17.28	85.43±16.24	3.103	0.002
T4	106.28±14.53	87.49±14.61	4.799	0.000
NF-κB
T0	9.68±1.12	9.25±2.36	1.509	0.133
T1	14.25±2.86	13.69±3.23	1.189	0.235
T2	20.18±3.83	16.47±6.54	4.486	0.000
T3	34.28±4.54	20.67±5.44	17.604	0.000
T4	54.19±5.75	24.08±7.72	28.668	0.000
Caspase-3
T0	2.35±0.56	2.42±0.76	0.679	0.498
T1	2.41±0.12	2.39±0.23	0.707	0.481
T2	2.92±0.25	2.87±0.35	1.065	0.288
T3	3.02±0.81	2.98±0.63	0.357	0.721
T4	3.11±0.43	2.97±0.85	1.347	0.179
IL-1β (ng/mL)
T0	62.49±10.03	59.63±12.85	1.608	0.109
T1	70.15±12.54	72.59±13.69	1.204	0.230
T2	82.55±14.49	83.49±13.82	0.430	0.667
T3	100.06±14.48	86.49±11.33	6.764	0.000
T4	123.59±16.26	90.48±16.69	13.023	0.000
TNF-α (ng/mL)
T0	87.54±12.26	90.36±17.82	1.195	0.233
T1	103.25±16.66	108.53±24.49	1.634	0.104
T2	145.62±20.15	151.87±29.54	1.602	0.111
T3	263.49±26.58	195.49±20.15	18.685	0.000
T4	350.48±27.69	261.45±24.44	22.093	0.000
TLR3
T0	8.56±1.21	8.34±1.43	1.076	0.283
T1	13.18±2.35	12.96±2.26	0.618	0.537
T2	19.32±4.51	11.46±5.68	9.933	0.000
T3	22.37±4.57	10.67±5.57	14.883	0.000
T4	28.38±6.52	9.09±6.76	18.824	0.000

Notes: T₀: before operation; T₁: 30 min after anesthesia induction; T₂: 24 h after operation; T₃: 48 h after operation; T₄: 72 h after operation; sCr: serum creatinine; IL: interleukin; TLR: toll-like receptor; TNF: tumor necrosis factor; DMED: dexmedetomidine; NF-κB: nuclear factor kappa B.