Table 1.
Correlation between total methylation level of MAGE-D4 promoter and clinical parameters in glioma patients
| Parameters | Methylation n (%) | P value | |
|---|---|---|---|
|
| |||
| High | Low | ||
| Gender | 0.000 | ||
| Male | 1 (8.3) | 35 (92.1) | |
| Female | 11 (91.7) | 3 (7.9) | |
| Age (years) | 0.185 | ||
| ≤37 | 8 (66.7) | 17 (44.7) | |
| >37 | 4 (33.3) | 21 (55.3) | |
| WHO Grade | 0.750 | ||
| I/II (Low grades) | 6 (50.0) | 21 (55.3) | |
| III/IV (High grades) | 6 (50.0) | 17 (44.7) | |
| Pathological type | 0.505 | ||
| astrocytoma | 7 (58.3) | 25 (65.8) | |
| anaplastic astrocytoma | 0 (0.0) | 3 (7.9) | |
| oligodendroglioma | 1 (8.3) | 1 (2.6) | |
| glioblastoma | 4 (33.3) | 9 (23.7) | |
| KPS Score | 0.768 | ||
| ≤70 | 10 (83.3) | 28 (73.7) | |
| >70 | 2 (16.7) | 10 (26.3) | |
| P53 Protein | 1.000 | ||
| - | 6 (50.0) | 19 (50.0) | |
| + | 6 (50.0) | 19 (50.0) | |
| Ki-67 (%) | 1.000 | ||
| <10 | 9 (75.0) | 27 (71.1) | |
| ≥10 | 3 (25.0) | 11 (28.9) | |
| Tumor Size (cm) | 0.508 | ||
| <5 | 5 (41.7) | 20 (52.6) | |
| ≥5 | 7 (58.3) | 18 (47.4) | |
| MAGE-D4 mRNA | 0.001 | ||
| High | 1 (8.3) | 24 (63.2) | |
| Low | 11 (91.7) | 14 (36.8) | |