Figure 4.

M2φ-Evs mitigates the nociception in CIBP mice by delivering miR-216a. (A) Microarray analysis of miRNA expression differences in spinal cord tissues from PBS-treated and M2φ-Evs-treated mice; (B) The heatmap showing the top 15 differentially expressed miRNAs; (C) The expression of the top six miRNAs in the spinal cord tissues of M2φ-Evs-treated mice examined by RT-qPCR; (D) Analysis of miR-216a distribution in cells via the RNAlocate website. **P < 0.01, ***P < 0.001 as determined by one-way ANOVA (C), followed by Tukey’s post-hoc analysis.