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HMGB1 promotes nociception in CIBP mice by activating the TLR4-NF-κB signaling pathway. (A) Western blot detection of expression of TLR4 and the extent of IKKB and NF-κB p65 phosphorylation in the spinal cord of mice; (B-D) Immunohistochemical staining intensity of TLR4 (B), phos-IKKB (C), and phos-NF-κB p65 (D) in spinal cord tissues. n = 8. **P < 0.01, ##P < 0.01, @@P < 0.01 as determined by one-way ANOVA (B-D) or two-way ANOVA (A), followed by Tukey’s post-hoc analysis.
