Table 1.
Association between SIX1 expression and clinical pathological characteristics of the EC patients
| characteristics | Total (N) | Odds ratio for SIX1 | 95% CI | P-value |
|---|---|---|---|---|
| Figo/T stage | ||||
| (II vs I) | 390 | 1.026032 | 0.5673105-1.852573 | 0.9318377 |
| (III vs I) | 463 | 1.102059 | 0.7300798-1.664599 | 0.643452 |
| (IV vs I) | 368 | 2.027439 | 0.9340816-4.66036 | 0.08135141 |
| Grade | ||||
| (G2 vs G1) | 218 | 1.409091 | 0.8182054-2.442822 | 0.2182168 |
| (G3 vs G1) | 423 | 0.2182168 | 1.366031-3.472236 | 0.001143322 |
| (G3 vs G2) | 445 | 1.812057 | 1.186491-2.788371 | 0.006300469 |
| M stage | ||||
| (M1 vs M0) | 543 | 1.079799 | 0.5084594-2.306641 | 0.8406878 |
| N stage | ||||
| (N1+N2 vs N0) | 535 | 1.062827 | 0.666531-1.69686 | 1.69686 |
| Histology | ||||
| (serous vs endometroid) | 537 | 0.8760947 | 0.5933435-1.291668 | 0.5044681 |
| Menopause status | ||||
| (post vs peri) | 461 | 1.135181 | 0.4265455-3.074648 | 0.7978767 |
| (pre vs peri) | 52 | 1.0625 | 0.331042-3.448223 | 0.9184371 |
| (pre vs post) | 479 | 0.9444444 | 0.4709182-1.886675 | 0.8707381 |
| Peritoneal cytology | ||||
| (Positive vs negative) | 407 | 2.535787 | 1.41898-4.691813 | 0.00216459 |
| With tumor vs tumor free | 462 | 2.290503 | 1.385172-3.868607 | 0.001500783 |
| Surgical approach | ||||
| (open vs mini-invisive) | 519 | 0.8044139 | 0.5641882-1.145442 | 0.2279554 |
SIX1, Sine oculis homeobox 1; EC, endometrial cancer; CI, confidence interval; Post, prior bilateral ovariectomy or >12 months since last menstrual period with no prior hysterectomy; Pre, <6 months since last menstrual period and no prior bilateral ovariectomy and not on estrogen replacement; Peri, 6-12 months since last menstrual period; P-values in bold print indicate statistically significant differences.