Table 2.
Comparisons of parameters of laboratory data, echocardiography and cardiopulmonary exercise tests (N = 688)
| Characteristic | TRACP5b < 316 (n = 229) | TRACP5b 316-489 (n = 229) | TRACP5b ≥ 490 (n = 230) | P |
|---|---|---|---|---|
| Laboratory data | ||||
| WBC, × 103/μL | 7.7 ± 4.2 | 7.2 ± 3.1 | 6.4 ± 2.2∗,† | < 0.001 |
| Hemoglobin, g/dL | 13.3 ± 2.1 | 13.0 ± 2.0 | 12.7 ± 2.3∗ | 0.003 |
| Iron, μg/dL | 82.3 ± 40.9 | 81.2 ± 42.7 | 79.5 ± 42.7 | 0.830 |
| Ferritin, ng/mL | 179.7 ± 334.8 | 287.9 ± 1698.4 | 376.8 ± 3112.1 | 0.696 |
| UIBC, μg/dL | 239.1 ± 75.7 | 234.7 ± 72.8 | 244.0 ± 78.5 | 0.534 |
| BUN, mg/dL | 19.7 ± 9.2 | 19.0 ± 9.1 | 23.0 ± 13.7∗,‡ | < 0.001 |
| Creatinine, mg/dL | 1.0 ± 0.5 | 1.0 ± 0.4 | 1.1 ± 0.9‡ | 0.009 |
| eGFR, mL/min/1.73 cm2 | 60.3 ± 22.3 | 59.8 ± 18.9 | 54.7 ± 23.5†,§ | 0.013 |
| Total protein, g/dL | 7.0 ± 0.8 | 7.0 ± 0.7 | 7.0 ± 0.8 | 0.897 |
| Albumin, g/dL | 3.9 ± 0.6 | 3.8 ± 0.6 | 3.8 ± 0.6 | 0.217 |
| ALP, IU/L | 237.0 ± 133.3 | 258.3 ± 87.4 | 300.2 ± 130.6 | < 0.001 |
| Magnesium, mg/dL | 1.7 ± 0.2 | 1.7 ± 0.2 | 1.8 ± 0.2∗,‡ | < 0.001 |
| Calcium, mg/dL | 9.0 ± 0.7 | 9.0 ± 0.6 | 9.1 ± 0.6 | 0.113 |
| Corrected calcium, mg/dL | 9.3 ± 0.5 | 9.4 ± 0.6 | 9.4 ± 1.0 | 0.453 |
| Phosphorus, mEq/L | 3.5 ± 0.7 | 3.6 ± 0.7 | 3.7 ± 0.6§ | 0.049 |
| TP1NP, μg/L | 35.2 ± 20.4 | 50.7 ± 52.9∗ | 77.5 ± 68.8∗,‡ | < 0.001 |
| OPG, pg/mL | 207.1 ± 136.9 | 219.0 ± 157.6 | 265.3 ±178.2 | 0.051 |
| Sodium, mmol/L | 139.4 ± 3.6 | 140.0 ± 3.0 | 139.2 ± 4.4 | 0.117 |
| Potassium, mmol/L | 4.3 ± 0.5 | 4.2 ± 0.5 | 4.2 ± 0.5 | 0.202 |
| Chloride, mmol/L | 104.1 ± 4.0 | 104.2 ± 3.6 | 103.1 ± 4.7† | 0.014 |
| CRP, mg/dL | 0.2 (0.1-0.9) | 0.2 (0.1-0.8) | 0.1 (0.1-0.6) | 0.495 |
| BNP, pg/mL | 163.8 (72.9-485.1) | 256.8 (93.3-562.1) | 338.9 (126.6-652.8) | 0.003 |
| Echocardiography | ||||
| LVEDV, mL | 119.2 ± 60.0 | 117.4 ± 64.2 | 118.4 ± 67.1 | 0.969 |
| LVESV, mL | 62.7 ± 49.0 | 63.9 ± 54.0 | 68.0 ± 55.0 | 0.658 |
| LVEF, % | 53.0 ± 16.6 | 51.4 ± 16.7 | 48.6 ± 16.8 | 0.081 |
| IVS, mm | 10.5 ± 2.4 | 10.4 ± 2.5 | 10.6 ± 2.7 | 0.775 |
| PW, mm | 10.5 ± 2.4 | 10.4 ± 2.0 | 10.7 ± 2.3 | 0.500 |
| LVMI, g/m2 | 121.2 ± 41.7 | 123.8 ± 43.0 | 132.0 ± 46.3 | 0.044 |
| Left atrial volume, mL | 72.4 ± 43.0 | 69.9 ± 45.2 | 73.9 ± 39.7 | 0.730 |
| TR-PG, mm Hg | 27.9 ± 16.3 | 29.2 ±17.4 | 29.9 ± 17.4 | 0.534 |
| IVC, mm | 15.5 ± 4.5 | 15.6 ± 4.6 | 15.2 ± 5.3 | 0.651 |
| RV FAC, % | 41.5 ± 17.2 | 38.0 ± 12.8 | 38.8 ± 13.3 | 0.278 |
| Cardiopulmonary exercise test, n = 250 | ||||
| Peak VO2, mL/kg/min | 15.6 ± 4.5 | 15.5 ± 5.0 | 13.9 ± 4.5 | 0.033 |
| VE/VCO2 slope | 33.1 ± 7.7 | 34.8 ± 9.3 | 36.7 ± 9.0§ | 0.034 |
Data are presented as mean ± SD or median (interquartile range) except where otherwise noted.
ALP, alkaline phosphatase; BNP, B-type natriuretic peptide; BUN, blood urea nitrogen; CRP, C-reactive protein; eGFR; estimated glomerular filtration rate; IVC, inferior vena cava; IVS, interventricular septum; LVEDV, left ventricular end-diastolic volume; LVEF, left ventricular ejection fraction; LVESV, left ventricular end-systolic volume; LVMI, left ventricular mass index; OPG, osteoprotegerin; PW, posterior wall; RV FAC, right ventricular fractional area change; TP1NP, total procollagen type I intact N-terminal propeptide; TRACP5b, tartrate-resistant acid phosphatase type 5b; TR-PG, tricuspid regurgitation pressure gradient; UIBC, unsaturated iron binding capacity; VE/VCO2 slope, slope of the relationship between ventilation and carbon dioxide production; VO2, breath-by-breath oxygen consumption; WBC, white blood cell count.
P < 0.01 vs first tertile.
P < 0.05.
P < 0.01 vs second tertile.
P < 0.05.