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. 2021 May 4;12:668002. doi: 10.3389/fimmu.2021.668002

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Copyright © 2021 Mao, Luo, Geng, Xu, Liao, Zhong, Ma, Tan, Xia, Duan, Song, Long, Liu, Yang, Wu and Jin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transcriptional profiles among the Con, LPS, Mel, and Luz groups. Volcano plots show the differentially expressed genes among the LPS vs Con (A), Mel vs LPS (B), and Luz vs Mel (C) three comparisons. The x-coordinate represents the log2FC and the y-coordinate represents -log10 (p value). Red points indicate significantly upregulated genes, blue points indicate significantly downregulated genes, and gray points indicate non-significantly different genes. (D) Functional GO enrichment analysis of differentially expressed genes among LPS vs Con, Mel vs LPS, and Luz vs Mel. (E) Histogram of significantly enriched metabolic pathways by MetaboAnalyst between Mel vs LPS (p value <0.05). The left ordinate represents −log10 (p value) and the right ordinate represents the number of genes in the metabolic pathway, and the upper abscissa represents the enhanced metabolic pathways. N = 6–8 in each group.