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. 2021 May 4;12:680585. doi: 10.3389/fphar.2021.680585

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Copyright © 2021 Zhang, Zhang, Zheng, Chen, Ji, Peng and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of XH on the production of NO, PGE₂, TNFα, and IL-6 in IL-1β-treated chondrocytes. (A) The production of NO was determined. (B) The production of PGE₂ was determined. (C) The production of TNFα was determined. (D) The production of IL-6 was determined. All experiments were performed in triplicate and data are presented as the mean ± standard deviation. *p < 0.05 and **p < 0.01. NC, negative control; Low, XH (5 μM); High, XH (20 μM).