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. 2021 May 4;12:680585. doi: 10.3389/fphar.2021.680585

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Copyright © 2021 Zhang, Zhang, Zheng, Chen, Ji, Peng and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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XH attenuated ECM degradation in IL-1β-treated chondrocytes. (A) The immunofluorescence study of MMP-13 in IL-1β-treated chondrocytes. (B) The summary data of fluorescence intensity of MMP-13. (C) The proteins expression of MMP-3, MMP-13, ADAMTS-4, ADAMTS-5, collagen-II, and aggrecan were detected by western blotting. (D–I) were the quantified values of tested proteins. All experiments were performed in triplicate and data are presented as the mean ± standard deviation. *p < 0.05 and **p < 0.01. NC, negative control; Low, XH (5 μM); High, XH (20 μM).