Table 1.

The information about the simulation parameters in the signaling network.

Index	Description	Mathematical representation	Parameter	Value	Remark
1	Deactivation of IKK		r 1	0.2 s−1	Rate of transition
2	Activation of IKK		r 2	0.4 s−1	Maximal rate of catalysis
			K 2	240 nM	Saturation coefficient of catalysis
			KI	10 nM	Inhibition coefficient of catalysis
			N	25	Hill coefficient
3	Phosphorylation of IκB		r 3	0.08 s−1	Maximal rate of catalysis
			K 3	500 nM	Saturation coefficient of catalysis
4	Dissociation of IκB/NF-κB complex		r 4	0.4 s−1	Dissociation rate
5	Degradation of IκB	d 5	d 5	0.8 nMs−1	Degradation rate
6	Association of IκB/NF-κB complex		r 6	0.008 nM−1s−1	Association rate
7	Synthesis of IκB		s7	0.8 s−1	Maximal rate of synthesis
			K7	50 nM	Saturation coefficient of synthesis
8	Synthesis of A20		s 8	0.4 s−1	Maximal rate of synthesis
			K 8	100 nM	Saturation coefficient of synthesis
9	Association of NF-κB with DNA		r 9	0.8 s−1	Transition rate
10	Dissociation of NF-κB from DNA		r 10	0.08 s−1	Transition rate
11	Degradation of A20	d 11	d 11	0.1 nMs−1	Degradation rate