TABLE 8.

List of selected compounds isolated from plant material with documented impact on NET formation.

	Plant-derived compound	Cellular target and mechanism of action	Effect on NET formation	References
1	Anacardic acid	Activation of PI3 kinase and surface-expressed G protein-coupled sphingosine-1-phosphate (S1P) receptors	Increased NET formation	Hollands et al. (2016)
2	Catechin hydrate	Decreased ROS production	Decreased NET formation	Kirchner et al. (2013)
3	Celastrol	Downregulation the SYK-mek-erk-nf?b signaling cascade	Decreased NET formation	Yu et al. (2015)
4	Epicatechin	Decreased ROS production	Decreased NET formation	Kirchner et al. (2013)
5	Polydatin	Decreased ROS production	Decreased NET formation	Liao et al. (2018)
6	Rutin trihydrate	Decreased ROS production	Decreased NET formation	Kirchner et al. (2013)

n.d.- not defined.