Skip to main content
. 2021 May 4;11:638537. doi: 10.3389/fonc.2021.638537

Figure 2.

Figure 2

Altering miR-454-3p expression modulates cell sensitivity to oxaliplatin in vitro. (A,B) Quantitative RT-PCR analysis on relative miR-454-3p expression after miR-454-3p was overexpressed in HCT-116 cells (A) or knockdown in HCT-116/OxR cells (B). (C,D) Inhibitory effects of oxaliplatin on cell viability determined by MTT assay. (C) HCT-116 cells transfected with miR-NC or miR-454-3p, and (D) HCT-116/OxR transfected with anti–miR-454-3p or anti–miR-NC. (E–G) Inhibitory effects of oxaliplatin on colony formation. (E,F) HCT-116 cells transfected with miR-NC or miR-454-3p, and (E,G) HCT-116/OxR transfected with anti–miR-454-3p or anti–miR-NC. Results were presented as mean ± SD from three independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001.