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. 2021 May 4;11:638537. doi: 10.3389/fonc.2021.638537

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Copyright © 2021 Qian, Zhou, Xu, Jiang, Chen, Wang, Zuo and Ni.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PTEN is a target of miR-454-3p. (A) Predicted miR-454-3p binding site in the 3′-UTR of PTEN. (B) Luciferase reporter assay confirmed that miR-454-3p bound to 3′-UTR of PTEN. (C) Western blotting assay showed the protein level of PTEN after overexpression or knockdown of miR-454-3p. **P < 0.01.