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. 2021 May 4;11:638537. doi: 10.3389/fonc.2021.638537

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Copyright © 2021 Qian, Zhou, Xu, Jiang, Chen, Wang, Zuo and Ni.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MiR-454-3p attenuates oxaliplatin-induced cell apoptosis through down-regulation of PTEN. (A–C) Cell apoptosis qualified by flow cytometry after annexin V–FITC and PI double staining in indicated cells treated with different concentrations of oxaliplatin. (D,E) Analysis of caspase-3 activity in indicated cells treated with different concentrations of oxaliplatin. Results were presented as mean ± SD from three independent experiments. *P < 0.05, **P < 0.01.