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. 2021 May 4;11:638537. doi: 10.3389/fonc.2021.638537

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Copyright © 2021 Qian, Zhou, Xu, Jiang, Chen, Wang, Zuo and Ni.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MiR-454-3p suppressed apoptosis and induced oxaliplatin resistance via activation of AKT pathway. (A) Western blotting on the expression of p-AKT, p-mTOR, total AKT, and total mTOR. β-Actin was used as an endogenous reference. (B,C) Cell viability determined by MTT assay in indicated cells treated with oxaliplatin and/or AKT signaling inhibitor LY294002. (D,E) Caspase-3 activity in indicated cells treated with different concentrations of oxaliplatin and/or LY294002. (F) Western blotting on the expression of apoptosis-related proteins, including Bax, Bcl-2, and cleaved caspase-3. Results were presented as mean ± SD from three independent experiments. *P < 0.05, **P < 0.01.