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. 2021 May 4;11:638537. doi: 10.3389/fonc.2021.638537

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Copyright © 2021 Qian, Zhou, Xu, Jiang, Chen, Wang, Zuo and Ni.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Up-regulation of miR-454-3p reduced the sensitivity of colorectal cancer cells to oxaliplatin in vivo. (A) Tumor xenografts with HCT-116 cells stably transfected with miR-454-3p or negative control. The mice received oxaliplatin every 4 days starting from the 8th day after tumor inoculation. (B) Representative images of dissected tumors in each group. (C) Quantitative RT-PCR analysis of the expression of miR-454-3p in representative tumor tissues. (D) A proposed mechanism of miR-454-3p mediated oxaliplatin resistance. **P < 0.01, ***P < 0.001.