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. 2021 May 4;12:641692. doi: 10.3389/fimmu.2021.641692

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Copyright © 2021 Ouk, Roland, Gachard, Poulain, Oblet, Rizzo, Saintamand, Lemasson, Carrion, Thomas, Balabanian, Espéli, Parrens, Soubeyran, Boulin, Faumont, Feuillard and Vincent-Fabert

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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B-cell differentiation in spleens from Cd19^Cre and Myd88^L252P mice. (A) Percentage of Follicular B cells (CD21^pos CD23^high) and marginal zone (MZ) B cells (CD21^high CD23^pos). (B) Percentage of plasma cells (PCs, B220^low CD138^high). (C) Percentage of IgM⁺ PCs and CD93^neg IgM PCs. Myd88^L252P mice (with normal SPE: n = 7; with hyper Ig: n = 10; with Ig peak: n = 9) were compared to Cd19^Cre mice LMCs (16-31 week and ≥ 32 week-old mice; n = 9 for each group) Results are presented as the mean ± SEM. Mann Whitney test p-value < 0.05, p-value < 0.01 and p-value < 0.001 are symbolized by *, ** and ***.