Table 15:
Clinical Parameters for the Budget Impact Analysis
| Variable | Mean | Reference |
|---|---|---|
| Emergency Department Setting | ||
| Standard clinical investigations | ||
| Sensitivity | 0.80 | Griffin et al 2017;54 NICE Acute HF guideline19 |
| Specificity | 0.77 | Griffin et al 2017;54 NICE Acute HF guideline19 |
| BNP ≤ 100 pg/mL | ||
| Sensitivity | 0.95 | Griffin et al 2017;54 NICE Acute HF guideline19 |
| Specificity | 0.63 | Griffin et al 2017;54 NICE Acute HF guideline19 |
| NT-proBNP ≤ 300 pg/mL | ||
| Sensitivity | 0.99 | NICE Acute HF guideline19 |
| Specificity | 0.43 | NICE Acute HF guideline19 |
| Community Care Setting | ||
| BNP ≤ 50 pg/mL | ||
| Sensitivity | 0.80 | Clinical evidence review |
| Specificity | 0.61 | Clinical evidence review |
| NT-proBNP ≤ 125 pg/mL | ||
| Sensitivity | 0.843 | NICE Chronic HF guideline20 |
| Specificity | 0.419 | NICE Chronic HF guideline20 |
Abbreviations: BNP, B-type natriuretic peptide; HF, heart failure; NT-proBNP, N-terminal proBNP.