. 2021 May 6;21(2):1–125.

Table 3:

Diagnostic Accuracy of NT-proBNP as Reported in Included Systematic Reviews

Author, Year	# Studies	Assays	Threshold/Cut Off, in pg/mL	Sensitivity (95% CI)	Specificity (95%CI)	PPV or LR+ (95% CI)	NPV or LR-(95% CI)	AUC/ROC (95%CI)	log DOR
Community/Outpatient Setting
NICE, 2018²⁰	6	Elecsys	67–2000	Range: 2–100	Range: 27–100	PPV range: 29–100	NPV range: 71–100	0.74–0.94	NR
	3		125	96 (72–100)	48 (18–80)	PPV range: 38–48	NPV range: 87–100	0.74–0.94	NR
Booth et al, 2014²⁵	20	Elecsys	25–6180	Range: 44–100	Range: 3–97	NR	NR	0.70–0.98	NR
	11		Optimum^a 87–424	86 (79–93)	58 (42–75)	2.18 (1.81–2.63)	0.23 (0.16–0.34)	0.85 (0.79–0.90)	2.50 (1.87–3.13)
Emergency Department/Acute Care Setting
Martindale et al, 2016²⁸	10	Elecsys, Dimension	300	90 (89–92)	38 (36–40)	1.8 (1.4–2.2)	0.09 (0.03–0.34)	NR	NR
Hill et al, 2014²⁶	4	Elecsys, Dimension	125–450	91 (88–93)	67 (50–80)	2.74 (1.74–4.32)	0.13 (0.10–0.19)	0.87 (0.79–0.95)	3.01 (2.34–3.69)
	19		Optimum^a	90 (85–93)	74 (67–81)	3.49 (2.72–4.49)	0.14 (0.10–0.20)	0.90 (0.87–0.93)	3.22 (2.80–3.64)
Mixed Setting
Taylor et al, 2018^29,b	7	Cardiac Reader (POC)	135	99 (57–100)	60 (44–74)	NR	NR	0.97 (0.57–1.00)	NR
NICE, 2014^19,c	10	Elecsys, Dimension	≤ 300	Range: 96–100	Range: 5–93	NR	NR	0.99 (0.98–1.00)	NR
	13		300–1800	Range: 75–98	Range: 49–93	NR	NR	0.90 (0.85–0.94)	NR

Abbreviations: AUC, area under the curve; CI, confidence interval; DOR, diagnostic odds ratio; LR, likelihood ratio; NPV, negative predictive value; NR, not reported; POC, point of care; PPV, positive predictive value; ROC, receiver operating characteristics curve.

The cut off points used by study authors varied among the different studies.

Included both primary and urgent care.

Included inpatient, intensive care unit, emergency department, and acute referral.