Table 17:

Variables in Scenario Analyses

Scenario	Reference Case	Scenario Analyses
Stepped care pathway is not an option	35% of people with TRD would switch to ECT if they did not initially respond to rTMS or iTBS	People with TRD would not receive ECT as second treatment if they did not initially respond to rTMS or iTBS and would transition to severe depression health state with sham therapy
Switching to ECT (stepped care pathway is an option)	35% of people with TRD would switch to ECT if depression did not initially respond to rTMS or iTBS	All people with TRD would receive ECT as second treatment if they did not initially respond to rTMS or iTBS
Time horizon	3 y	1 y or lifetime
Discount rate	1.5%	3%
Increase in mortality due to severe depression	29%	±25%

Abbreviations: ECT, electroconvulsive therapy; iTBS, intermittent theta burst stimulation; rTMS, repetitive transcranial magnetic stimulation; TRD, treatment-resistant depression.