Table A11:
Adverse Events Reported by Included Primary Studies (Part 1)
| Author, Year | Headache | Scalp Discomfort | Paina | Fatigue | Dizzinessb | Insomniac | Eye Problemsd | Nasal Problemse | Ear Problemsf | Mouth Problemsg | GI Issuesh |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Anderson et al, 200778 | rTMS 2/11 Sham 0/14 | ||||||||||
| Avery et al, 199979 | rTMS 4/4 Sham 2/2 | ||||||||||
| Avery et al, 200680 | rTMS 11/33 Sham 1/30 | ||||||||||
| Bakim et al, 201273 | rTMS 4/23 Sham 1/12 | rTMS 2/23 Sham 0/12 | |||||||||
| Berman et al, 200081 | rTMS 6/10 Sham 5/10 | ||||||||||
| Blumberger et al, 201283 | rTMSi 1/22 Sham 0/15 | rTMSi 1/22 Sham 0/15 | |||||||||
| Blumberger et al, 201682j | Bi 7/40 Uni 7/40 Sham 7/41 | Bi 7/40 Uni 10/40 Sham 3/41 | Bi 2/40 Uni 2/40 Sham 1/41 | Bi 1/40 Uni 0/40 Sham 0/41 | Bi 3/40 Uni 2/40 Sham 1/41 | Bi 1/40 Uni 0/40 Sham 0/41 | Bi 1/40 Uni 0/40 Sham 0/41 | Bi 1/40 Uni 2/40 Sham 1/41 | |||
| Boutros et al, 2002186 | rTMS 8/12 Sham 5/9 | rTMS 3/12 Sham 1/9 | rTMS 1/12 Sham 0/9 | ||||||||
| Fitzgerald et al, 200386j | rTMS 6/40 Sham 0/40 | rTMS 2/40 Sham 1/40 | |||||||||
| Fitzgerald et al, 2006a106 | rTMS 5/25 Sham 2/22 | rTMS 3/25 Sham 0/22 | |||||||||
| Garcia-Toro et al, 200188 | rTMS 6/17 Sham 0/18 | ||||||||||
| George et al, 201089k | rTMS 29/92 Sham 23/98 | rTMS 17/92 Sham 10/98 | rTMS 0/92 Sham 1/98 | rTMS 5/92 Sham 4/98 | rTMS 2/92 Sham 0/98 | rTMS 7/92 Sham 10/98 | rTMS 6/92 Sham 3/98 | ||||
| Herwig et al, 200791 | rTMS 3/52 Sham 1/53 | rTMS 1/52 Sham 2/53 | rTMS 0/52 Sham 1/53 | rTMS 1/52 Sham 0/53 | |||||||
| Kaster et al, 201848 | rTMS 14/25 Sham 10/27 | rTMS 4/25 Sham 0/27 | rTMS 1/25 Sham 0/27 | rTMS 1/25 Sham 0/27 | rTMS 2/25 Sham 0/27 | rTMS 1/25 Sham 1/27 | rTMS 1/25 Sham 1/27 | ||||
| Levkovitz et al, 2015126 | rTMS 27/89 Sham 21/92 | rTMS 8/89 Sham 2/92 | rTMS 0/89 Sham 3/92 | rTMS 2/89 Sham 4/92 | |||||||
| Li et al, 2014109 | cTBS 1/15 iTBS 3/15 Bi TBS 1/15 Sham 2/15 | cTBS 1/15 iTBS 2/15 Bi TBS 5/15 Sham 1/15 | cTBS 0/15 iTBS 2/15 Bi TBS 1/15 Sham 0/15 | ||||||||
| Loo et al, 2003120 | rTMS 3/9 Sham 0/10 | rTMS 5/9 Sham 0/10 | rTMS 1/9 Sham 0/10 | ||||||||
| Loo et al, 200793 | rTMS 8/18 Sham 0/18 | rTMS 15/18 Sham 0/18 | rTMS 1/18 Sham 0/18 | rTMS 4/18 Sham 0/18 | rTMS 0/18 Sham 1/18 | ||||||
| Mantovani et al, 2013104 | rTMS 2/12 Sham 3/13 | rTMS 1/12 Sham 2/13 | rTMS 2/12 Sham 2/13 | ||||||||
| Mogg et al, 2008113 | rTMS 0/28 Sham 1/29 | rTMS 0/28 Sham1/29 | |||||||||
| Mosimann et al, 200494 | rTMS 0/15 Sham 2/9 | rTMS 0/15 Sham 1/9 | rTMS 3/15 Sham 0/9 | rTMS 2/15 Sham 0/9 | rTMS 1/15 Sham 2/9 | ||||||
| O'Reardon et al, 200795 | rTMS 18/165 Sham 2/158 | rTMS 84/165 Sham 12/158 | rTMS 10/165 Sham 3/158 | rTMS 12/165 Sham 1/158 | |||||||
| Plewnia et al, 2014125 | rTMS 2/16 Sham 3/16 | rTMS 1/16 Sham 0/16 | rTMS 1/16 Sham 0/16 | ||||||||
| Rossini et al, 2005114l | 100% 2/18 80% 2/18 Sham 0/16 | 100% 3/18 80% 0/18 Sham 0/16 | |||||||||
| Su et al, 200574 | rTMS 2/10 Sham 1/10 | ||||||||||
| Tavares et al, 2017110 | rTMS 9/20 Sham 10/23 | rTMS 5/20 Sham 0/23 | rTMS 11/20 Sham 10/23 | rTMS 5/20 Sham 2/23 | |||||||
| Theleritis et al, 201775m | rTMS 3/25 Sham 1/18 | rTMS 7/25 Sham 1/18 | |||||||||
| Triggs et al, 201076 | rTMS 7/18 Sham 3/7 | rTMS 6/18 Sham 1/7 | rTMS 1/18 Sham 0/7 | rTMS 5/18 Sham 2/7 | rTMS 3/18 Sham 1/7 | rTMS 1/18 Sham 1/7 | rTMS 1/18 Sham 0/7 | rTMS 4/18 Sham 0/7 | |||
| Yesavage et al, 201850 | rTMS 15/73 Sham 16/77 | rTMS 8/73 Sham 8/77 | |||||||||
| Total | rTMS 183/784 Sham 116/616 | rTMS 93/620 Sham 21/573 | rTMS 137/563 Sham 34/517 | rTMS 14/190 Sham 7/146 | rTMS 18/404 Sham 6/326 | rTMS 15/279 Sham 16/238 | rTMS 20/250 Sham 3/229 | rTMS 10/98 Sham 8/104 | rTMS 7/140 Sham 3/102 | rTMS 16/285 Sham 2/235 | rTMS 22/370 Sham 8/290 |
Abbreviations: Bi, bilateral; cTBS, continuous theta burst stimulation; GI, gastrointestinal; iTBS, intermittent theta burst stimulation; rTMS, repetitive transcranial magnetic stimulation; TBS, theta burst stimulation; Uni, unilateral.
Includes skin pain, back pain, facial pain, sore hip, muscle aches, neck pain and stiffness, scraping feeling, dermatitis, burning sensation.
Includes light-headedness, feeling “high,” vertigo.
Includes difficulty sleeping, nightmares.
Includes eye pain, tearfulness, conjunctivitis, corneal abrasion, crying.
Includes sinusitis, nasopharyngitis.
Includes tinnitus, difficulty hearing.
Includes toothache, metallic taste, aphthous ulcer.
Includes nausea, flu, vomiting.
Adverse events in unilateral high-frequency left dorsolateral prefrontal cortex group.
Adverse events reported separately for each group (bilateral rTMS, unilateral high-frequency rTMS, sham).
Combined adverse events in both active rTMS groups (high frequency and low frequency).
Also reported “other” adverse events (rTMS 18/92, sham 15/98).
Adverse events reported by group (100% motor threshold, 80% motor threshold, sham).
Adverse events reported in active rTMS and sham TMS groups that received 1 treatment session daily.