Table A8:
Response Rates for rTMS Modalities Versus Sham Treatment
| Author, Year | No. of Studies (Active + Sham TMS) | Results | Definition of Response Rate |
|---|---|---|---|
| All rTMS Modalitiesa | |||
| University of Calgary, 201734b | 31 (NR) | RR 2.35 (95% CI 1.70-3.25, P = .025) I2 = 36.1% Favouring rTMS |
≥ 50% reduction |
| HF Left DLPFC | |||
| Health Quality Ontario, 201618 | 18 (NR) | RR 1.72 (95% CI 1.1-2.62, P = .011) I2 = 46.4% Favouring rTMS |
≥ 50% reduction |
| Mutz et al, 201835 | 25 (566) | OR 4.31 (95% CI 2.66-6.99, P = NR) I2 = NR Favouring rTMS |
≥ 50% reduction |
| Sehatzadeh et al, 201941 | 17 (NR) | RR 2.00 (95% CI 1.26-3.19, P = .01) I2 = 50.4% Favouring rTMS NNT = 8 |
≥ 50% reduction |
| Bilateral rTMS | |||
| Zhang et al, 201543 | 7 (NR) | RR 3.29 (95% CI 1.69-6.38, P = .004) I2 = 0% Favouring rTMS |
≥ 50% reduction |
| Sehatzadeh et al, 201941 | 7 (NR) | RR 3.55 (95% CI 1.87-6.76, P = .86) I2 = 0% Favouring rTMS NNT = 6 |
≥ 50% reduction |
| All TBS modalitiesc | |||
| Berlim et al, 201745 | 6 (118 + 103) | OR 2.7 (95% CI 1.4-5.3, P = .005) I2 = 0% Favouring TBS |
≥ 50% reduction |
| iTBS | |||
| Mutz et al, 201835 | 2 (NR) | OR 4.70 (95% CI 1.14-19.38, P = NR) I2 = 0% Favouring iTBS |
≥ 50% reduction |
| cTBS | |||
| Mutz et al, 201835 | 1 (NR) | OR 1.63 (95% CI 0.23-11.46, P = NR) I2 = NR No difference |
≥ 50% reduction |
| Deep TMS | |||
| Nordenskjold et al, 201644 | 1 (89 + 92) | Deep TMS 37.0% Sham deep TMS 27.8% P = .03 Favouring deep TMS |
≥ 50% reduction |
| Mutz et al, 201835 | 2 (NR) | OR 1.69 (95% CI 1.00-2.85, P = NR) I2 = 0% Favouring deep TMS |
≥ 50% reduction |
Abbreviations: CI, confidence interval; cTBS, continuous theta burst stimulation; DLPFC, dorsolateral prefrontal cortex; HF, high frequency; iTBS, intermittent theta burst stimulation; NNT, number needed to treat; NR, not reported; OR, odds ratio; RR, risk ratio; rTMS, repetitive transcranial magnetic stimulation; TBS, theta burst stimulation; TMS, transcranial magnetic stimulation.
a
Includes high-frequency, low-frequency, and bilateral rTMS.
b
Same results as results of Leggett et al.40
c
Includes two unilateral cTBS, two unilateral iTBS, and three bilateral TBS.