Median OS (95% CI) in years in patients with MYC abnormality (blue curve) and without MYC abnormality (red curve) a) overall and among those who received b) PI-based, c) IMiD-based and d) PI+IMiD-based first line treatment. Abbreviations: Abn: abnormality, IMiD: immunomodulatory drug, NR: not reached, OS: overall survival, PI: proteasome inhibitor.