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. Author manuscript; available in PMC: 2021 Aug 18.
Published in final edited form as: Clin Cancer Res. 2020 Oct 2;26(24):6581–6588. doi: 10.1158/1078-0432.CCR-20-2283

Table 2: Univariate and multivariate models.

Univariate and multivariate analysis including MYC rearrangement, HR cytogenetic abnormalities, ISS stage and age ≥70. Abbreviations: HR: high-risk, ISS: international staging system, OS: overall survival, RR: risk ratio.

Variable Univariate Multivariate (HR FISH
abnormalities only)		 Multivariate (All)
OS RR
(95%CI)		 P
Value		 OS RR
(95%CI)		 P
value		 OS RR
(95%CI)		 P
value
MYC rearrangement 1.7
(1.3-2.2)		 <0.001 1.7
(1.3-2.2)		 <0.001 1.5
(1.1-2.0)		 0.01
HR IgH translocation 2.0
(1.6-2.5)		 <0.001 1.6
(1.3-2.0)		 <0.001 1.9
(1.5-2.5)		 <0.001
Del(17p) 2.0
(1.6-2.5)		 <0.001 2.0
(1.5-2.5)		 <0.001 1.6
(1.2-2.1)		 <0.001
1q gain/amplification 1.9
(1.6-2.3)		 <0.001 1.7
(1.4-2.0)		 <0.001 1.4
(1.2-1.8)		 0.001
ISS stage III 1.9
(1.6-2.3)		 <0.001 - - 1.7
(1.4-2.1)		 <0.001
Age ≥ 70 2.1
(1.8-2.5)		 <0.001 - - 2.3
(1.8-2.8)		 <0.001