Table 1.
CSF results of all three patients treated with pembrolizumab.
| Number of LPs: | Patient 1 |
Patient 2 |
Patient 3 |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 1 (external) | 2 | 3 | 4 | 1 (external) | 2 | 3 | 1 (external) | 2 | 3 | |
| Time since first symptoms (weeks) | 2 | 6 | 13 | 17 | 1 | 4 | 16 | 8 | 12 | 17 |
| CSF cells/µl | 3 | 5 | 4 | 4 | 5 | 8 | 36 | 1 | 3 | 12 |
| CSF protein (mg/l) | 370 | 410 | 480 | 500 | 820 | 1390 | 860 | 300 | 330 | 420 |
| Qalbumin | 5.1 | 5.8 | 6.4 | 8.6 | N/A | 21.6 | 15.6 | 4.3 | 4.2 | 4.9 |
| CSF lactate (mmol/l) | 1.6 | 1.8 | 1.6 | 1.6 | 1.2 | 1.7 | 1.7 | 1.6 | n.d. | 2.0 |
| OCBs | Negative | Negative | Negative | Negative | N/A | Positive (type 3) | Positive (type 3) | Negative | Positive (type 2a) | Negative |
| JCPyV PCR (c/ml) | Negative | <500 | 780 | 220 | Negative | Negative | Negative | 500 | 90.000 | 190.000 |
| AIJCV | n.d. | Negative | Negative | Negative | n.d. | 5.2 | 6.3 | n.d. | Negative | Negative |
AIJCV, JCPyV antibody index; CSF, cerebrospinal fluid; JCPyV, JC polyoma virus; LP, lumbar puncture; N/A, not applicable; n.d., not done; OCB, oligoclonal band; PCR, polymerase chain reaction.