Table 1.
Characteristics at Baseline and 2 Years after ETV Commencement
| Characteristics | Baseline (n=359) | At 2 year after ETV commencement (n=359) | p-value |
|---|---|---|---|
| Age, yr | 51±10 | ||
| Male sex | 231 (64.3) | ||
| AST, IU/L | 126±161 | 34±14 | <0.001 |
| ALT, IU/L | 130±171 | 31±17 | <0.001 |
| Albumin, g/dL | 3.7±0.6 | 4.1±0.5 | <0.001 |
| Total bilirubin, mg/dL | 1.9±2.6 | 1.3±1.0 | <0.001 |
| INR | 1.27±0.28 | 1.14±0.57 | <0.001 |
| Platelet count, ×103/μL | 102±41 | 107±44 | <0.001 |
| HBeAg positivity | 177 (49.3) | 127 (37.7) | <0.001 |
| HBV DNA, log10 copies/mL | 7.0±1.2 | 0.2±0.8 | <0.001 |
| CP class | <0.001 | ||
| A | 254 (70.8) | 322 (89.7) | |
| B | 89 (24.8) | 34 (9.5) | |
| C | 16 (4.4) | 3 (0.8) | |
| MELD | 8.4±4.6 | 6.2±4.2 | <0.001 |
| APRI | 3.6±4.6 | 1.5±1.5 | <0.001 |
| FIB-4 index | 6.8±5.9 | 3.9±2.7 | <0.001 |
Data are presented as mean±SD or number (%).
ETV, entecavir; AST, aspartate aminotransferase; ALT, alanine aminotransferase; INR, international normalized ratio; HBeAg, hepatitis B e antigen; HBV, hepatitis B virus; CP, Child-Pugh; MELD, Model for End-Stage Liver Disease; APRI, aspartate transaminase to platelet ratio index.