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. 2021 May 18;6:197. doi: 10.1038/s41392-021-00611-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A NAbs IC₅₀ titer by focus reduction neutralization test (FRNT) vs NAbs IC₅₀ titer by surrogate virus neutralization test (sVNT); B NAbs IC₅₀ titer by FRNT vs logit of sVNT neutralization rate at 1:20 dilution of sera (logit NR₂₀); C NAbs IC₅₀ titer by sVNT vs logit NR₂₀; D NAbs IC₅₀ titer by FRNT vs the level of total binding IgG. The blue lines are the regression lines between two measurements estimated by Deming regression. ρ Spearman’s correlation coefficients, S/CO ratio of the chemiluminescence signal over the cutoff value