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The overall model development, verification process, and simulation flow chart. Abbreviations: b.i.d., twice daily; CLint, intrinsic clearance; CYP, cytochrome P450; DDI, drug‐drug interaction; Fa, fraction absorbed; fmcyp3A4,fraction of drug metabolized by CYP3A4; PBPK, physiologically based pharmacokinetics; q.d., once daily; Vsac, volume of the single adjusted compartment.
