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. 2021 May 1;10(5):467–477. doi: 10.1002/psp4.12610

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© 2021 The Authors. CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Simulated pyridoxic acid (PDA) plasma concentrations assuming the effect of OAT1/3 inhibitor also on biomarker synthesis (k_syn). Hypothetical ratio of 0 (continuous line) corresponds to no effect on PDAk _syn. The values of 0.1 (dotted line), and 10 (dashed line) represent 10‐fold lower and higher, respectively, inhibitory effect on PDAk _syn than the effect on OAT1/3‐mediated CL_r of the biomarker. Scenarios simulated following (a) multiple doses of probenecid (500 mg every 6 h) or (b) single dose of probenecid (1000 mg)