Table 3.
Characteristics of Subjects With the Highest Predicted Mortality
| Characteristic | BODE Group | Model Group | P Value |
|---|---|---|---|
| No. of subjects | 466 | 466 | |
| Age, mean (SD), y | 64.51 (8.25) | 68.03 (7.03) | < .001 |
| Race, African American, No. (%) | 81 (17.4) | 46 (9.9) | .001 |
| Sex, female, No. (%) | 211 (45.3) | 162 (34.8) | .001 |
| Total dead, No. (%) | 259 (55.6) | 290 (62.2) | .046 |
| Days followed up, median (IQR) | 1,809 (1,068-2,442) | 1,350 (914-2,230) | .002 |
| BODE, median (IQR) | 7.00 (7.00-8.00) | 7.00 (6.00-8.00) | < .001 |
| 6-Min walk distance, mean (SD), ft | 644.85 (281.57) | 692.98 (293.03) | .011 |
| FEV1 % predicted, median (IQR) | 28.60 (21.40-34.60) | 28.60 (21.60-36.40) | .548 |
| mMRC dyspnea score, No. (%) | < .001 | ||
| 0 | 0 (0.0) | 7 (1.5) | |
| 1 | 0 (0.0) | 22 (4.7) | |
| 2 | 27 (5.8) | 102 (21.9) | |
| 3 | 162 (34.8) | 173 (37.1) | |
| 4 | 277 (59.4) | 162 (34.8) | |
| FEV1/FVC ratio, median (IQR) | 0.35 (0.29-0.42) | 0.34 (0.28-0.39) | .001 |
| FEF25%-75%, median (IQR), L | 0.24 (0.19-0.33) | 0.24 (0.18-0.31) | .573 |
| Resting SaO2, median (IQR) | 94.00 (92.00-96.00) | 93.00 (91.00-96.00) | .002 |
| Exacerbation frequency, mean (SD), No./y | 1.25 (1.52) | 1.41 (1.47) | .101 |
| Pack-years cigarette smoking, median (IQR) | 49.00 (36.00-73.12) | 54.00 (40.00-80.00) | .002 |
| BMI, mean (SD), kg/m2 | 26.17 (6.94) | 25.39 (5.59) | .059 |
| Severe exacerbations, No. (%) | 190 (40.8) | 215 (46.1) | .113 |
| PA:A ratio, mean (SD) | 0.95 (0.16) | 0.99 (0.16) | < .001 |
| Pi10, mean (SD) | 3.91 (0.30) | 4.06 (0.37) | < .001 |
| Diabetes, No. (%) | 52 (11.2) | 66 (14.2) | .2 |
| % LAA < −950 HU, median (IQR) | 25.30 (14.01-37.02) | 24.62 (15.82-35.04) | .979 |
The BODE group with the highest predicted mortality had BODE score 7 to 10 (see Materials and Methods). See Table 1 and 2 legends for expansion of abbreviations.