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. 2021 May 14;220(7):e202007005. doi: 10.1083/jcb.202007005

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© 2021 Badmos et al.

This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

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Figure 9. — Schematic illustration. (A) Depiction of not’s role in BC migration. (B) Depiction of the effect of not loss of function (LOF) on protein complexes described in the text. In conjunction with other factors, Not associates with, and regulates the expression of, ex and mer, which function to anchor the Hippo complex, including Crb, to the BC–BC junction, suppressing Ena-driven F-actin (purple) formation there. The expression of other genes is also likely to be affected. Crb is displaced in not LOF, and F-actin accumulates at the BC–BC junction, leading to tumbling of the cluster.