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. 2021 May 18;373:n1022. doi: 10.1136/bmj.n1022

Table 3.

Hepatitis C virus antibody screening at 12 months

Substudy Completed antibody screening, n (%; 95% CI)* Difference, % (95% CI) P value†
Substudy A: opt in or opt out
 Letter only (n=813) 279 (34.3; 31.1 to 37.6) 21.9 (17.2 to 26.6) <0.001
 Letter+laboratory order (n=829) 466 (56.2; 52.8 to 59.6)
Substudy B: content
 Usual care messaging (n=9828) 2855 (29.0; 28.2 to 29.9) −0.9 (−2.2 to 0.3) 0.15
 Behavioral messaging (n=9833) 2765 (28.1; 27.2 to 29.0)
Substudy B: communication mode
 Mailed letter (n=1897) 638 (33.6; 31.5 to 35.8) −4.4 (−6.7 to −2.1) <0.001
 Patient portal message (n=9498) 2778 (29.3; 28.3 to 30.2)
*

Includes only patients screened using antibody testing.

P value less than 0.05 was threshold for statistical significance using χ2 test of proportions.