. 2021 May 18;7(1):e12183. doi: 10.1002/trc2.12183

TABLE 3.

Associations between dietary patterns and CSF biomarker pathology

Model 1 ^a					Model 2 ^a
Aβ42 (60/209) ^d (60/208) ^e	OR	95% CI	S.E	P‐value	OR	95% CI	S.E	P‐value
Western	1.30	0.95;1.78	0.16	.10	1.30	0.90;1.89	0.19	.17
Mediterranean/prudent	0.99	0.74;1.32	0.15	.94	0.89	0.65;1.23	0.16	.49
High‐protein and alcohol	0.98	0.73;1.31	0.15	.88	0.84	0.59;1.19	0.18	.33
High‐total and saturated fat	0.98	0.74;1.29	0.14	.87	0.89	0.66;1.20	0.15	.44

Aβ42/Aβ40 ^b (76/190) ^d (76/189) ^e	OR	95% CI	S.E	P‐value	OR	95% CI	S.E	P‐value
Western	1.22	0.92;1.64	0.15	.17	1.25	0.88;1.76	0.18	.21
Mediterranean/prudent	1.06	0.81;1.38	0.14	.67	0.90	0.67;1.21	0.15	.48
High‐protein and alcohol	0.92	0.70;1.20	0.14	.53	0.80	0.58;1.12	0.17	.19
High‐total and saturated fat	0.96	0.74;1.24	0.13	.76	0.90	0.68;1.19	0.14	.45

Aβ42+Tau ^c (27/242) ^d (27/241) ^e	OR	95% CI	S.E	P‐value	OR	95% CI	S.E	P‐value
Western	1.81	1.14;2.86	0.23	.01	1.79	1.03;3.10	0.28	.04
Mediterranean/prudent	1.01	0.68;1.15	0.20	.95	0.92	0.60;1.41	0.22	.70
High‐protein and alcohol	0.96	0.64;1.44	0.21	.86	0.68	0.42;1.12	0.25	.13
High‐total and saturated fat	1.15	0.79;1.68	0.19	.47	1.03	0.68;1.56	0.21	.88

T‐tau (84/185) ^d (84/184) ^e	OR	95% CI	S.E	P‐value	OR	95% CI	S.E	P‐value
Western	1.36	1.02;1.80	0.14	.04	1.43	1.02;2.01	0.17	.04
Mediterranean/prudent	0.97	0.75;1.26	0.13	.83	0.94	0.71;1.26	0.15	.68
High‐protein and alcohol	0.92	0.71;1;20	0.13	.54	0.71	0.51;0.98	0.17	.04
High‐total and saturated fat	1.11	0.87;1.43	0.13	.40	1.10	0.84;1.45	0.14	.50

P‐tau (14/255) ^d (14/254) ^e	OR	95% CI	S.E	P‐value	OR	95% CI	S.E	P‐value
Western	0.89	0.51;1.57	0.29	.69	0.87	0.44;1.73	0.35	.87
Mediterranean/prudent	0.92	0.54;1.59	0.28	.78	0.74	0.40;1.36	0.31	.33
High‐protein and alcohol	0.97	0.56;1.67	0.28	.90	0.93	0.49;1.76	0.33	.82
High‐total and saturated fat	1.42	0.86;2.34	0.26	.17	1.40	0.79;2.48	0.29	.26

^{^a}

Analyses in model 1 is unadjusted for confounders. Potential confounders that have been included in model 2 are: BMI, energy intake, sex, physical activity level, and educational level. One participant had missing physical activity level data.

^{^b}

Three participants had missing Aβ42/40 ratio values.

^{^c}

Aβ42+Tau stands for Aβ42 + total tau and/or phosphorylated tau pathology (n = 27). There were 22 participants with pathological Aβ42+total tau levels. The participants with pathological Aβ42+phosphorylated tau (n = 5) levels all had pathological total tau levels as well.

^{^d}

Number of participants with CSF biomarker pathology/number of participants who did not have pathological levels in the unadjusted model.

^{^e}

Number of participants with CSF biomarker pathology/number of participants who did not have pathological levels in the adjusted model.